What's Heart Failure with Preserved Ejection Fraction (HFpEF)? Heart failure is a condition by which the heart muscle is unable to pump enough blood to satisfy the body’s nutrition and oxygen wants. We classify heart failure based on which of these two functions is abnormal. If the center muscle is simply too weak, the condition is called heart failure with a diminished ejection fraction (HFrEF). Ejection fraction is used to evaluate the pump function of the center; it represents the proportion of blood pumped from the left ventricle (the main pumping chamber) per beat. A standard ejection fraction is larger than or equal to 50 %. There are various causes for a weak coronary heart muscle (low ejection fraction). If the guts pumps normally however is just too stiff to fill correctly, the situation is called coronary heart failure with preserved ejection fraction (HFpEF). Current research means that HFpEF occurs when chronic medical conditions harm the center and the opposite organ methods of the body.